Most People Get GLP-1 Wrong: Here's What Works
Spencer Nadolsky, DOPublished on June 12, 2026
Summary authored by editor@wellifi.com
TLDR Summary
Dr. Spencer Nadolsky provides essential tips for patients using GLP-1 medications like Zepbound and Wegovy, emphasizing the importance of not prematurely increasing the dose, adopting a healthier diet, and maintaining adequate fiber intake. By following these recommendations, patients can optimize their weight management journey while minimizing side effects.
Key Points
- Do not increase your GLP-1 dose unless necessary.
- Shift to a healthier diet instead of just reducing food intake.
- Avoid completely eliminating your appetite; aim to normalize it.
- Incorporate resistance training to preserve muscle mass.
- Optimize protein intake without overdoing it.
- Focus on getting enough fiber to manage side effects.
Top Tips for Optimizing Your Experience with GLP-1 Medications
GLP-1 medications, such as Zepbound and Wegovy, have gained popularity as effective tools for weight management. However, many patients feel lost after receiving a prescription without adequate guidance. In this article, Dr. Spencer Nadolsky, a board-certified obesity physician, shares essential tips on what to do and what to avoid while using these medications to enhance your journey.
What to Avoid When Taking GLP-1 Medications
1. Don’t Increase Your Dose Prematurely
One of the most significant mistakes is increasing the dose of your GLP-1 medication without necessity. Dr. Nadolsky emphasizes the importance of a "low and slow" approach. If you are losing weight effectively without side effects, there’s no reason to escalate your dose. A rule of thumb is to aim for a weight loss of about 0.5% to 1% of your total body weight per week. For instance, if you weigh 300 pounds, aim for a weight loss of 1.5 to 3 pounds per week. Increasing your dose too soon can lead to unwanted side effects like nausea and constipation.
2. Avoid Just Eating Less of Your Previous Diet
Many individuals mistakenly believe that they can simply eat less of their usual diet. While the appetite-suppressing effects of GLP-1 medications can help reduce cravings, it’s crucial to shift towards a healthier dietary pattern. High-fat foods, in particular, can exacerbate side effects, especially when starting the medication. Instead, opt for a diet rich in lean proteins, vegetables, and high-fiber foods.
3. Don’t Eliminate Your Appetite Completely
Some patients aim to starve themselves by cranking up their medication doses, leading to the complete elimination of appetite. Dr. Nadolsky cautions against this approach, as it can result in negative health effects, including gallbladder issues and muscle loss. The goal should be to normalize your appetite, ensuring you nourish your body adequately for overall health and energy levels.
What You Should Do Instead
1. Incorporate Resistance Training
Lifting weights is vital for preserving muscle mass while losing weight on GLP-1 medications. Dr. Nadolsky recommends a minimum of 30 minutes of resistance training twice a week. This can effectively help maintain muscle and prevent loss during weight reduction.
2. Optimize Your Protein Intake
While protein is important, it's essential not to overdo it. Aim for about 1 to 1.2 grams of protein per kilogram of body weight. For example, if you weigh 220 pounds (approximately 100 kilograms), target around 100 to 120 grams of protein per day. This balanced approach can help preserve muscle while you lose fat.
3. Focus on Fiber Intake
Fiber is critical for managing potential side effects like constipation, which can occur while on GLP-1 medications. Dr. Nadolsky suggests aiming for 30 to 40 grams of fiber daily, which can be sourced from fruits, vegetables, legumes, and whole grains. If necessary, consider fiber supplements to meet your intake goals.
Conclusion
Managing your health journey while on GLP-1 medications can be challenging, but following these tips can lead to a more successful experience. Remember to lift weights, optimize your protein and fiber intake, and avoid unnecessary dose adjustments. For further information and resources, you can access Dr. Nadolsky's free starter guide.